armadillo repeat proteins
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila ’armadillo’ gene product, that are typically 42 to 45 amino acids in length.
These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences.
Members
| CTNNDs | CTNND1 | CTNND2 | ||
| PKPs | PKP1 | PKP2 | PKP3 | PKP4 |
| ARVCF |
delta-1-catenin CTNND1 (MIM.601045)
delta-2-catenin CTNND2 (MIM.604275)
plakophilin-1 PKP1 (MIM.601975)
plakophilin-2 PKP2 (MIM.602861)
plakophilin-4 PKP4
ARVCF (armadillo repeat gene deleted in velocardiofacial syndrome)(MIM.602269)
References
Tolwinski NS, Wieschaus E. Rethinking WNT signaling. Trends Genet. 2004 Apr;20(4):177-81. PMID: 15041171