adrenal cytomegaly
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Adrenal cytomegaly is still not well known. It is characterized by the presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex. Adrenal cytomegaly is found in 0.8% pediatric autopsies.
Synopsis
large polyhedral cells in the adrenal cortex
- eosinophilic granular cytoplasm
- enlarged nuclei
false intranuclear inclusions (6264884)
Etiology (Exemples)
Beckwith-Wiedemann syndrome (1849635, 2845376)
isolated (3778124, 3838445)
- in adults (3778124)
Associations
diaphragmatic hernia (10879233)
Case records
References
Ong BB, Wong KT. Adrenal cytomegaly associated with diaphragmatic hernia: report of a case.Malays J Pathol. 1996 Dec;18(2):121-3. PMID: 10879233
Fasano M, Greco MA. Proliferative activity of adrenal glands with adrenocortical cytomegaly measured by MIB-1 labeling index. Pediatr Pathol Lab Med. 1996 Sep-Oct;16(5):765-76. PMID: 9025875
Favara BE, Steele A, Grant JH, Steele P. Adrenal cytomegaly: quantitative assessment by image analysis. Pediatr Pathol. 1991 Jul-Aug;11(4):521-36. PMID: 1946074
Camuto PM, Wolman SR, Perle MA, Greco MA. Flow cytometry of fetal adrenal glands with adrenocortical cytomegaly. Pediatr Pathol. 1989;9(5):551-8. PMID: 2813201
Yamashina M. Focal adrenocortical cytomegaly observed in two adult cases. Arch Pathol Lab Med. 1986 Nov;110(11):1072-5. PMID: 3778124
Feuerstein IM, Tiamson EM. Focal cytomegaly of the adult adrenal cortex. A rare variant of black adenoma. Arch Pathol Lab Med. 1985 Feb;109(2):198-200. PMID: 3838445
Nakamura Y, Yano H, Nakashima T. False intranuclear inclusions in adrenal cytomegaly. Arch Pathol Lab Med. 1981 Jul;105(7):358-60. PMID: 6264884
Gau GS, Bennett MJ. Fetal adrenal cytomegaly. J Clin Pathol. 1979 Mar;32(3):305-6. PMID: 429599
Marsden HB, Zakhour HD. Cytomegalic adrenal hypoplasia with pituitary cytomegaly. Virchows Arch A Pathol Anat Histol. 1978 Jun 2;378(2):105-10. PMID: 149412
Mamelle JC, David M, Riou D, Gilly J, Trouillas J, Dutruge J, Gilly R. [Congenital adrenal hypoplasia of cytomegalic type. Recessive, sex-linked form. Apropos of 3 cases] Arch Fr Pediatr. 1975 Feb;32(2):139-59. French. PMID: 1217948
Aterman K, Kerenyi N, Lee M. Adrenal cytomegaly. Virchows Arch A Pathol Pathol Anat. 1972;355(2):105–122.
Niggemeyer H, Sandhage K. [Thymus gland hyperplasia: congenital, in association with adrenal gland hypoplasia and cytomegaly or myocarditis respectively]. Klin Padiatr. 1972 Nov;184(6):501-7. PMID: 4346363
Borit A, Kosek J. Cytomegaly of the adrenal cortex. Electron microscopy in Beckwith’s syndrome. Arch Pathol. 1969 Jul;88(1):58-64. PMID: 5793692
Birdwell TR, Dimmette RM. Cytomegaly of the adrenal gland. An interesting finding: report of three cases. Am J Clin Pathol. 1967 May;47(5):585–587.