acute promyelocytic leukemia
Associations
mitoxantrone therapy for multiple sclerosis (18406875)
Cytogenetics
Acute promyelocytic leukemia (APL) is typically associated with the t(15;17) that generates the PML-RARA fusion protein.
Animal models have shown that although the fusion protein is necessary, it is insufficient for the development of APL, implying that additional mechanisms are responsible for full-blown leukemia.
CGH (16419057)
losses
- 1p36 loss
- 2p11 loss
- 16p loss
- 17p loss
gains
- 8p gain
- 8q gain
- 13q gain
These results suggest that chromosomal imbalances are largely absent in APL, although some nonrandom chromosomal imbalances could be linked to the development of APL in a limited number of cases.
References
Karnan S, Tsuzuki S, Kiyoi H, Tagawa H, Ueda R, Seto M, Naoe T. Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia. Genes Chromosomes Cancer. 2006 Apr;45(4):420-5. PMID: 16419057
Reviews
Lallemand-Breitenbach V, Zhu J, Kogan S, Chen Z, de The H. Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia. Nat Rev Cancer. 2005 Oct;5(10):821-7. PMID: 16175176
Zhu J, Chen Z, Lallemand-Breitenbach V, de The H. How acute promyelocytic leukaemia revived arsenic. Nat Rev Cancer. 2002 Sep;2(9):705-13. PMID: 12209159
Pandolfi PP. Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.
Hum Mol Genet. 2001 Apr;10(7):769-75. PMID: 11257111
Lin RJ, Egan DA, Evans RM. Molecular genetics of acute promyelocytic leukemia. Trends Genet. 1999 May;15(5):179-84. PMID: 10322484