Hashimoto thyroiditis
MIM.140300
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Hashimoto thyroiditis. Thyroid autoimmunity
Synospsis
interstitial lymphocytic infiltration
interstitial fibrosis
defect in thyroid basement membrane
+/- Hashimoto tyroiditis-associated papillary thyroid carcinoma (17660159)
Biology
thyroid autoantibodies
- anti-microsme antibodies
abnormal, small, iodinated protein in the serum
Predisposition
autosomal dominant inheritance
Locus 2q33: CTLA4 (MIM.123890)
Locus 6p11: AITD1 (MIM.608173)
Locus 5q31-q33: AITD2 (MIM.608174)
Locus 8q24: AITD3 (MIM.608175)
Locus 10q: AITD4 (MIM.608176)
Locus 18q21: AITD5 (MIM.601941)
References
Paolieri F, Pronzato C, Battifora M, Fiorino N, Canonica GW, Bagnasco M. Infiltrating gamma/delta T-cell receptor-positive lymphocytes in Hashimoto’s thyroiditis, Graves’ disease and papillary thyroid cancer. J Endocrinol Invest. 1995 Apr;18(4):295-8. PMID: 7560812