ETSs
The ETSs proteins are transcription factors which activate transcription by interaction with purine-rich sequences present in the promoter/enhancer region of the TCRA gene (MIM.186880).
Members
| ETSs | ETS1 | ETS2 | ||||
| FLI1 | ERG | FEV | ||||
| ELKs | ELK1 | ELK2 | ||||
| ETVs | ETV1 | ETV2 | ETV3 | ETV4 | ETV5 | ETV6 |
The several classes of ETS family members could be due to an ancestral gene duplication, followed by genetic recombination(s) or divergence. Since all of the classes are present in both invertebrates and vertebrates, such an ancestral duplication must predate the emergence of chordates more than 500 million years ago.
Pathology
overexpression of the ETSs genes in the majority of prostate cancers
- gene fusions of the 5’-untranslated region of TMPRSS2 (21q22.3) with the ETS transcription factor family members, either ERG (21q22.2), ETV1 (7p21.2), or ETV4 (17q21) (16951139)
References
Perner S, Demichelis F, Beroukhim R, Schmidt FH, Mosquera JM, Setlur S, Tchinda J, Tomlins SA, Hofer MD, Pienta KG, Kuefer R, Vessella R, Sun XW, Meyerson M, Lee C, Sellers WR, Chinnaiyan AM, Rubin MA. TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer. Cancer Res. 2006 Sep 1;66(17):8337-41. PMID: 16951139
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, Lee C, Montie JE, Shah RB, Pienta KJ, Rubin MA, Chinnaiyan AM. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005 Oct 28;310(5748):644-8. PMID: 16254181