ESR1
MIM.133430 6q25
Cancer
Oestrogen receptor-alpha (ERalpha or ESR1)-regulated transcription in breast cancer cells involves protein co-factors that contribute to the regulation of chromatin structure.
These include co-factors with the potential to regulate histone modifications such as acetylation or methylation, and therefore the transcriptional state of target genes.
Much of the information regarding the interaction of specific co-factors with ER has been generated by studying specific promoter regions.
Pathology
estrogen receptor alpha (ESR1) gene amplification (6q25 amplicon) is frequent in mammary adenocarcinoma (breast cancer) (17417639)
References
Green KA, Carroll JS. Oestrogen-receptor-mediated transcription and the influence of co-factors and chromatin state. Nat Rev Cancer. 2007 Sep;7(9):713-22. PMID: 17721435
Holst F, Stahl PR, Ruiz C, Hellwinkel O, Jehan Z, Wendland M, Lebeau A, Terracciano L, Al-Kuraya K, Janicke F, Sauter G, Simon R. Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet. 2007 Apr 8; PMID: 17417639