CARDs
CARDs are a family of intracellular proteins that contain an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and a C-terminal regulatory domain.
Members
| CARD1 | CARD2 | CARD3 | CARD4 | CARD5 | CARD6 | CARD7 | CARD8 | CARD9 | CARD10 |
| CARD11 | CARD12 | CARD13 | CARD14 | CARD15 |
Function
Proteins containing CARD, or related DD or DED, motifs are centrally involved in assembling protein complexes that drive activation of either IkappaB kinase or caspases by facilitating intermolecular juxtapositioning.
CARD-family proteins (CARDs) occupy crucial positions in divergent stress-associated signalling pathways that culminate in inflammatory responses or apoptosis.
Pathology
| CARD15 | susceptibility to Crohn disease |
| CARD15 | Blau syndrome |
References
Hiscott J, Lin R, Nakhaei P, Paz S. MasterCARD: a priceless link to innate immunity. Trends Mol Med. 2006 Feb;12(2):53-6. PMID: 16406812
Martin SJ. Dealing the CARDs between life and death. Trends Cell Biol. 2001 May;11(5):188-9. PMID: 11393153