TNM Staging System
T stages of salivary gland cancer
T1 means the tumour is all inside the tissue of the salivary gland and is smaller than 2cm across (about ¾ inch across)
T2 – the tumour is larger than 2cm, but smaller than 4cm across (about 1 ½ inches)
T3 – the tumour is bigger than 4cm and/or it has spread into the soft tissues around the salivary gland
T4a – the tumour has grown outside the salivary gland into nearby body tissues such as the jaw, ear canal, facial nerves or skin (...)
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Most recent articles
TNM Staging System
sebaceous epithelial-myoepithelial carcinoma of the parotid gland
Epithelial-myoepithelial carcinoma (EMCa) is a double-cell layered low-grade malignant tumor, representing approximately 1% of all salivary gland tumors.
Its histologic characteristic is that of an inner layer of cuboidal epithelial cells with dense granular cytoplasm and central or basal rounded nucleus, and an outer layer of clear, polygonal myoepithelial cells, together forming ductal structures in a lobulated papillary (...)
DICER1-associated renal sarcoma DICER1-associated renal rhabdomyosarcoma
DICER1-associated cystic nephroma
DICER1-associated sex cord tumors
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma. Doros LA, Rossi CT, Yang J, Field A, Williams GM, Messinger Y, Cajaiba MM, Perlman EJ, A Schultz K, Cathro HP, Legallo RD, LaFortune KA, Chikwava KR, Faria P, Geller JI, Dome JS, Mullen EA, Gratias EJ, Dehner LP, Hill DA.
Mod Pathol. 2014 Sep;27(9):1267-80. doi:10.1038/modpathol.2013.242 . PMID: #24481001# (...)
NB: A 8 kg historical tumor. (#10560870#)
Correlation of MUC4 expression with clinical outcomes may establish MUC4 as a potential molecular prognostic marker for these tumors. (#11226945#)
MUC4 (sialomucin complex) expression in salivary gland tumors and squamous cell carcinoma of the upper aerodigestive tract. Weed DT, Gomez-Fernandez C, Bonfante E, Lee TD, Pacheco J, Carvajal ME, Goodwin WJ, Carraway KL. Otolaryngol Head Neck Surg. 2001 Feb;124(2):127-41. PMID: (...)
primary parotid squamous cell carcinoma
secondary parotid squamous cell carcinoma
A primary of secondary lesions
In a series, 75% of patients have previous epidermoid skin lesions in an area known to drain to the parotid gland and 10% result from direct extension into the gland from an overlying skin carcinoma, whereas only 10% are primary lesions of the gland.
In this series (#3823246#), patients who presented with involvement of the gland more than 4 months after excision of (...)
fine needle aspiration of parotid masses
Selective fine needle aspiration of parotid masses. FNA should be performed in all patients older than 60 years. Kieran SM, McKusker M, Keogh I, Timon C. J Laryngol Otol. 2010 Sep;124(9):975-9. doi:10.1017/S0022215110001088 . PMID: #20497621#
A misdiagnosed keratoacanthoma turned out to be a metastatic parotid carcinoma. Tas E, Birol Ugur M, Gul A, Cinar F, Uzun L, Dogan Gun B. Acta Otorhinolaryngol Ital. 2010 Apr;30(2):115-7. PMID: #20559484#
Oral and oropharyngeal SCC can metastasize to the intraparotid lymph nodes. The inferior parotid nodes are most commonly involved, and patients generally have substantial associated cervical metastases.
When treating patients who have oral or oropharyngeal cancer with substantial cervical metastasis, physicians should consider removing the inferior parotid lymph nodes.
When intraparotid lymph node metastasis is detected, total parotidectomy and multidisciplinary adjuvant therapy should be (...)
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