Humpath.com - Human pathology

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• splenic infectious mononucleosis

  18 May

  PO
  Microscopy
  expansion of red pulp immunoblastic proliferation in red pulp Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells immunoblastic infiltration of subintima of intratrabecular veins Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
  red pulp hemophagocytosis
  Differential diagnosis
  Hodgkin lymphoma
  splenic localization of leukemia
  splenic (...)

• spleen in hereditary spherocytosis

  18 May

  PO
  Digital slides
  UI:742 : spleen in hereditary spherocytosis.
  Macroscopy
  Microscopy
  marked congestion of red pulp
  empty appearance of sinuses (actually contain ghost red blood cells)
  * may have prominent endothelial lined sinuses
  red pulp hemosiderin deposition
  red pulp erythrophagocytosis
  Videos
  Hereditary spherocytosis by Washington Deceit
  See also
  erythrocytic (...)

• spleen in hemolytic anemia

  18 May

  Types of hemolytic anemia
  congenital hemolytic anemia hereditary spherocytosis sickle cell anemia
  acquired hemolytic anemia deposition of immune complexes on red blood cell membranes bacterial hemolysins plasma lipid abnormalities parasites
  immune hemolytic anemia brucellosis Hodgkin lymphoma leukemia sarcoidosis SLE (lupus) tuberculosis
  Microscopy
  splenic congestion in cords and sinuses
  splenic hemosiderin deposition
  splenicextramedullary hematopoiesis (...)

• spleen in AIDS

  18 May, by Admin

  Prior to highly active antiretroviral therapy (HAART), typical findings were:
  white pulp depletion
  red pulp hemosiderin deposition
  splenic spindle cell proliferation
  splenic perivascular hyalinization
  also infectious and malignant infiltrates (Mod Pathol 2002;15:406)
  Post-highly active antiretroviral therapy (HAART) findings include less frequent white pulp depletion, but similar rates of splenic involvement by atypical mycobacteria and CMV in those with systemic (...)

• splenic lymphoplasmocytic lymphoma

  18 May

  PO
  Differential diagnosis
  SLL/CLL
  splenic marginal zone B cell lymphoma (SMZL)

• splenic follicular lymphoma

  18 May

  follicular lymphoma of the spleen
  PO
  Differential diagnosis
  reactive splenic lymphoid hyperplasia - splenic nodular lymphoid hyperplasia
  See also
  splenic red pulp nodules

• splenic red pulp nodules

  18 May

  Etiology
  splenic lymphomas splenic diffuse large B-cell lymphoma (splenic DLBCL) splenic follicular lymphomas
  splenic metastasis

• splenic diffuse large B cell lymphoma

  18 May

  splenic DLBCL; DLBCL of the spleen
  PO

• nodular transformation of the red pulp

  18 May

  Etiology
  red pulp lymphomas
  carcinomatous infiltration
  References
  Nodular transformation of splenic red pulp due to carcinomatous infiltration. A diagnostic pitfall. Fakan F, Michal M. Histopathology. 1994 Aug;25(2):175-8. PMID: #7982681#

• splenic diffuse red pulp small-B cell lymphoma

  18 May

  Among splenic lymphomas with circulating cells presenting cytoplasmic projections, a homogeneous clinico-pathological entity has been recently individualized as Splenic Diffuse Red Pulp Lymphomas (SDRPL) and introduced in the provisional "unclassifiable splenic lymphoma" category of the current updated WHO classification until more is known.
  SDRPL presents characteristic circulating basophilic villous lymphocytes and diffuse infiltration of the splenic red pulp, distinct from Splenic (...)

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