Humpath.com - Human pathology

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• CA-125

  22 May

  WP PO
  CA-125 (cancer antigen 125 or carbohydrate antigen 125) also known as "mucin 16" or "MUC16" is a protein that in humans is encoded by the MUC16 gene.
  MUC16 is a member of the mucin family glycoproteins.
  CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions.

• mediastinal lymph nodes

  21 May

• Bowenoid papulosis

  20 May

  Bowenoid papulosis consists of one or more indolent, verrucous papules on the genitalia with a clinical resemblance to condyloma acuminatum and a histological resemblance to Bowen’s disease.
  HPV-16 is the most frequently detected HPV subtype detected in this condition. It usually responds to local therapies, but recurrences and the development of invasive carcinoma have been reported.
  The term ‘penile intraepithelial neoplasia’ (PIN) has been coined to encompass the three preinvasive (...)

• penile intraepithelial neoplasia

  20 May

  The term ‘penile intraepithelial neoplasia’ (PIN) has been coined to encompass the three preinvasive clinical entities of:
  penile Bowen disease
  erythroplasia of Queyrat
  bowenoid papulosis.

• intraepidermal carcinoma

  20 May

  intraepidermal carcinomas
  Although the term ‘intraepidermal carcinoma’ is often used synonymously with Bowen disease, it is used here in a broader sense to include not only carcinoma in situ of the skin (Bowen’s disease), and penis (erythroplasia of Queyrat), but also intraepidermal epithelioma of Jadassohn, a controversial entity of disputed histogenesis.
  Paget’s disease is sometimes included in this category because of the presence of cytologically malignant cells within the epidermis. (...)

• splenic amyloidosis

  19 May

  spleen amyloidosis
  PO
  Synopsis
  Macroscopy
  firm consistency
  waxy consistency
  possible sago spleen
  possible lardaceous spleen
  splenomegaly
  diffuse splenic infiltration
  possible localized splenic nodules
  rare splenic rupture
  Microscopy
  splenic deposition of pink amorphous material deposition of pink amorphous material limited either to germinal follicles (sago spleen) deposition of pink amorphous material along splenic sinusoids deposition of pink amorphous material in (...)

• splenic infectious mononucleosis

  18 May

  PO
  Microscopy
  expansion of red pulp immunoblastic proliferation in red pulp Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells immunoblastic infiltration of subintima of intratrabecular veins Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
  red pulp hemophagocytosis
  Differential diagnosis
  Hodgkin lymphoma
  splenic localization of leukemia
  splenic (...)

• spleen in hereditary spherocytosis

  18 May

  PO
  Digital slides
  UI:742 : spleen in hereditary spherocytosis.
  Macroscopy
  Microscopy
  marked congestion of red pulp
  empty appearance of sinuses (actually contain ghost red blood cells)
  * may have prominent endothelial lined sinuses
  red pulp hemosiderin deposition
  red pulp erythrophagocytosis
  Videos
  Hereditary spherocytosis by Washington Deceit
  See also
  erythrocytic (...)

• spleen in hemolytic anemia

  18 May

  Types of hemolytic anemia
  congenital hemolytic anemia hereditary spherocytosis sickle cell anemia
  acquired hemolytic anemia deposition of immune complexes on red blood cell membranes bacterial hemolysins plasma lipid abnormalities parasites
  immune hemolytic anemia brucellosis Hodgkin lymphoma leukemia sarcoidosis SLE (lupus) tuberculosis
  Microscopy
  splenic congestion in cords and sinuses
  splenic hemosiderin deposition
  splenicextramedullary hematopoiesis (...)

• spleen in AIDS

  18 May, by Admin

  Prior to highly active antiretroviral therapy (HAART), typical findings were:
  white pulp depletion
  red pulp hemosiderin deposition
  splenic spindle cell proliferation
  splenic perivascular hyalinization
  also infectious and malignant infiltrates (Mod Pathol 2002;15:406)
  Post-highly active antiretroviral therapy (HAART) findings include less frequent white pulp depletion, but similar rates of splenic involvement by atypical mycobacteria and CMV in those with systemic (...)

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