Patterns and functional implications of rare germline variants across 12 cancer types.
Lu C, Xie M, Wendl MC, Wang J, McLellan MD, Leiserson MD, Huang KL, Wyczalkowski MA, Jayasinghe R, Banerjee T, Ning J, Tripathi P, Zhang Q, Niu B, Ye K, Schmidt HK, Fulton RS, McMichael JF, Batra P, Kandoth C, Bharadwaj M, Koboldt DC, Miller CA, Kanchi KL, Eldred JM, Larson DE, Welch JS, You M, Ozenberger BA, Govindan R, Walter MJ, Ellis MJ, Mardis ER, Graubert TA, Dipersio JF, Ley TJ, (...)
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This degenerative and inflammatory lesion of the stomach clinically simulate gastric carcinoma because of the extensive involvement of the mucosa and submucosa by the process.
Histologically, it is characterized by eosinophilic hyalinoid degeneration of smooth muscles in the muscularis mucosae as well as mucosal and submucosal blood vessels accompanied with foreign body giant cells and other inflammatory cells.
The lesion occurred in association with chronic peptic ulcers, and a small (...)
Gastric inverted hyperplastic polyp (IHP) is a rare type of gastric polyp, and is characterized by downward growth of the hyperplastic mucosal components into the submucosa.
The lesions are mainly composed of hyperplastic foveolar-type glands with focal cystic dilatation.
Pyloric type glands, endocrine cells, acinic cell metaplasia, and smooth muscle bundles were also seen as components of the polyp.
Some cases can coexist with multifocal gastritis cystica profunda (GCP) and gastric (...)
Gastric adenocarcinoma with chief cell differentiation: a proposal for reclassification as oxyntic gland polyp/adenoma. Singhi AD, Lazenby AJ, Montgomery EA. Am J Surg Pathol. 2012 Jul;36(7):1030-5. doi:10.1097/PAS.0b013e31825033e7 . PMID: #22472957#
Reactive gastropathy refers to the constellation of endoscopic and histologic findings caused by chemical injury to the gastric mucosa.
The histologic picture is characterized by foveolar hyperplasia with edema, smooth muscle hyperplasia, and congestion of superficial capillaries in the lamina propria in the absence of significant inflammation.
These features were originally described in biopsy specimens obtained from patients who had undergone gastric surgery and were felt to be specific (...)
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