mammary peri-prothetic capsula
Formation of a fibrous envelope around the implant, a so-called capsule with resultant contracture of the prosthesis, is an occasional complication of augmentation mammoplasty.
The capsulectomy specimen contains mature scar tissue with mononuclear cells, histiocytes, and foreign body giant cells.
Studies showed a striking form of papillary villous synovial-like hyperplasia similar to detritic synovitis, a form of proliferative synovitis caused by orthopedic (...)
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mammary peri-prothetic capsula
silicon foreign body reaction
capsular synovial-like hyperplasia around mammary implants similar to detritic synovitis (#7694944#)
silicone lymphadenopathy ( #3377110#)
anaplastic large cell lymphoma (ALCL) of the breast (#18594466#)
Primary lymphomas of the breast are rare and predominately of B-cell phenotype.
Anaplastic large cell lymphoma is a T-cell lymphoma that accounts for only 3% of all non-Hodgkin lymphomas.
Rare cases of primary anaplastic large cell (...)
pediatric non-Helicobacter pylori atrophic gastritis
Although autoimmune atrophic gastritis is classically a disease of elderly adults, recent studies have described the disease in younger adults, particularly in those with other autoimmune diseases and iron-deficiency anemia. Atrophic gastritis in pediatrics is a rare and possibly underdiagnosed entity.
Pediatric Non-Helicobacter Pylori Atrophic Gastritis: A Case Series. Pogoriler J, Kamin D, Goldsmith JD. Am J Surg Pathol. (...)
Papillary adenocarcinoma is another common histologic variant often seen in early gastric carcinoma. It tends to affect older people, occur in the proximal stomach, and is frequently associated with liver metastasis and a higher rate of lymph node involvement. Histologically, it is characterized by epithelial projections scaffolded by a central fibrovascular core.
micropapillary carcinoma of stomach
Micropapillary carcinoma of stomach is a newly recognized histologic variant characterized by small papillary clusters of tumor cells without a distinct fibrovascular core.
The micropapillary features are often noted in the deep advancing edge of tumor, surrounded by an empty space mimicking retraction artifact.
Micropapillary carcinoma of stomach, as its counterpart at other organs, tends to form endolymphatic tumor emboli and metastasize to lymph (...)
Mucin production in primary liver neoplasms is typically interpreted as evidence for biliary differentiation. However, it has been observed benign and malignant liver tumors that have abundant extracellular myxoid/mucinous material, yet have only evidence of hepatocellular differentiation.
Extracellular myxoid/mucinous material in isolation should not be interpreted as cholangiocarcinoma. Furthermore, the unique morphology, the clinical characteristics, and the immunophenotype results (...)
inflammatory pseudotumors inflammatory myofibroblastic tumor plasma cell granuloma fibrous pseudo-tumor
nodular lymphoid hyperplasia
Pulmonary pseudoneoplasms. Yi E, Aubry MC. Arch Pathol Lab Med. 2010 Mar;134(3):417-26. doi: 10.1043/1543-2165-134.3.417. PMID: (...)
Cavitary pulmonary coccidioidomycosis: pathologic and clinical correlates of disease. Sobonya RE, Yanes J, Klotz SA. Hum Pathol. 2014 Jan;45(1):153-9. doi:10.1016/j.humpath.2013.08.014 .PMID: #24321524#
ALK-associated Spitz nevus
Activating kinase fusions have recently been described as early oncogenic events that are mutually exclusive with HRAS and BRAF mutations in Spitz tumors.
high frequency of chromosome 2 aberrations (where ALK resides, 63%)
chromosome 1p loss (37%)
In a series (#25602801#), Spitz tumors with ALK fusions demonstrated unique histopathologic features. Clefts and small vesicle-like spaces were (...)
Cutaneous lymphomas of both B cells and less commonly T cells can exceptionally exhibit spindle-cell morphology.
Less than 30 spindle-cell B-cell lymphomas of the skin have been described, mostly before the adoption of detailed immunohistochemistry, and thus initially interpreted as variants of diffuse large B-cell lymphoma (DLBCL). Furthermore, some authors suggest that cutaneous spindle-cell B-cell lymphomas (cSCBCLs) may behave more aggressively than their conventional morphologic (...)
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