Humpath.com - Human pathology

Most recent articles

• pleural nodular lymphoid hyperplasia

  17 May

  pleural follicular lymphoid hyperplasia
  See also
  pleural lymphoid hyperplasia

• BAP1 cancer syndrome

  17 May

  BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21.
  Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms.
  Germline BAP1 mutations are associated with a novel cancer syndrome characterized by malignant mesothelioma, uveal melanoma, cutaneous melanoma and "melanocytic BAP1-mutated atypical intradermal tumors" (MBAITs), and possibly by other cancers.
  MBAITs (...)

• BAP1-mutated mesothelioma

  17 May

  See also
  BAP1-mutated tumors
  Open references
  BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. Carbone M, Ferris LK, Baumann F, Napolitano A, Lum CA, Flores EG, Gaudino G, Powers A, Bryant-Greenwood P, Krausz T, Hyjek E, Tate R, Friedberg J, Weigel T, Pass HI, Yang H. J Transl Med. 2012 Aug 30;10:179. doi: 10.1186/1479-5876-10-179 . PMID: #22935333# [Free]
  References
  Molecular pathogenesis of malignant mesothelioma. Sekido Y. Carcinogenesis. (...)

• BAP1-mutated tumors

  17 May

  BAP1-associated tumors
  References
  BAP1 and cancer. Carbone M, Yang H, Pass HI, Krausz T, Testa JR, Gaudino G. Nat Rev Cancer. 2013 Mar;13(3):153-9. PMID: #23550303#
  Tumours associated with BAP1 mutations. Murali R, Wiesner T, Scolyer RA. Pathology. 2013 Feb;45(2):116-26. doi: 10.1097/PAT.0b013e32835d0efb . PMID: #23277170#
  The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics. Abdel-Wahab O, Dey A. Leukemia. 2013 Jan;27(1):10-5. doi: 10.1038/leu.2012.288 . PMID: (...)

• lung adenocarcinoma with fetal lung–like morphology

  17 May

  Low-grade lung adenocarcinoma of fetal lung type, which is well characterized by its unique clinicopathologic and molecular features, is recognized as a distinct variant of lung cancer.
  High-grade lung adenocarcinoma with fetal lung–like morphology (HG-LAFM) is caracterized by at least a focal component resembling a developing epithelium in the pseudoglandular phase of the fetal lung.
  These rare (ca. 0.4%) carcinomas occurred predominantly in elderly men with a heavy smoking history, who (...)

• YWHAE-associated endometrial stromal sarcoma

  14 May

  Pathology
  YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas (#23599159#) Endometrial stromal sarcomas represent the second most common mesenchymal uterine tumor. The 2003 WHO classification distinguishes low-grade and undifferentiated endometrial stromal sarcomas with different prognoses. Endometrial stromal sarcomas are a genetically heterogeneous group of sarcomas harboring different cytogenetic anomalies. A fusion between the YWHAE and FAM22A/B genes (...)

• simple renal cyst

  13 May

  Simple renal cysts
  Simple kidney cysts are abnormal, fluid-filled sacs that form in the kidneys.
  Simple kidney cysts do not enlarge the kidneys, replace their normal structure, or cause reduced kidney function like cysts do in people with PKD.
  Simple kidney cysts are more common as people age. An estimated 25 percent of people 40 years of age and 50 percent of people 50 years of age have simple kidney (...)

• intra-articular lipoma

  12 May

  Subtypes
  intra-articular lipoma arborescens

• synovial hypertrophy

  12 May

  Under typical conditions, the normal synovial lining may not be visible or is barely visible. When synovial hypertrophy is present, it covers the joint, often altering the normal contour of the joint capsule.
  Normally, the joint capsule follows joint anatomy, but it may bulge outward when there is synovial hypertrophy, and it may even change from a concave to a convex shape.
  The synovial thickness has a huge span, ranging from very minimal hypertrophy to severe hypertrophy with villi, (...)

• hypertrophic synovitis

  12 May

  Hypertrophic synovitis is fairly common in the foot and ankle as a result of an injury or in reaction to silicone implants.
  See also
  familial hypertrophic synovitis
  synovial hypertrophy

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