DD in pleural pathology
humpath.com supports the 2015 edition of the European Symposium of Biopathology, June 2015 in Paris, France.
Most recent articles
BRMH vs mesothelial neoplasia; benign vs malignant mesothelial proliferations
Even seasoned surgical pathologists who have established expertise in the diagnosis of malignant mesothelioma (MM) can disagree about whether a pleural biopsy represents MM or atypical epithelioid mesothelial hyperplasia (AEMH).
When this question arises, the pathologist is well advised to inquire into the clinical features, radiographic findings, and the surgeon’s assessment of the pleura at the time of (...)
Erionite is a naturally occurring fibrous mineral that belongs to a group of minerals called zeolites. It usually is found in volcanic ash that has been altered by weathering and ground water. Erionite forms brittle, wool-like fibrous masses in the hollows of rock formations and has an internal molecular structure similar to chabazite.
Some properties of erionite are similar to the properties of asbestos; however, erionite is NOT currently regulated by the U.S. Environmental (...)
Among crocidolite asbestos miners in South Africa, the incidence of MM was about 4.7% (20/423 deaths). Therefore, the challenge is to identify the reasons that make some individuals more susceptible or possibly more resistant to asbestos carcinogenesis.
A first consideration is the amount and length of exposure. For example, among the 20 deaths that occurred in the crocidolite miners mentioned above,2 6 were in individuals exposed from 12 to 95 months, 6 in miners (...)
Pyloric gland adenoma (#24518125#)
Pyloric gland adenoma in Lynch syndrome. Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM. Am J Surg Pathol. 2014 Jun;38(6):784-92. doi:10.1097/PAS.0000000000000185 . PMID: #24518125# (...)
cysts of the penis
Cysts arising in the penis are uncommon and can be found anywhere from the urethral meatus to the root of the penis involving glans, foreskin or shaft.
median raphe cyst of the penis
epidermal inclusion cyst
cysts of lymphatic origin
Shao, I.H., Chen, T.D., Shao, H.T. et al. Male median raphe cysts: serial retrospective analysis and histopathological classification. Diagn Pathol. 2012; 7: 121
Garcia Serrado, D., (...)
GI (especially colonic) biopsies can establish a diagnosis of SM in patients with GI symptoms. GI involvement is usually subtle and is often associated with prominent eosinophils, which may obscure the mast cell infiltrate.
KIT and CD25 are invaluable markers for the diagnosis. Mast cell density in colonic mucosa from asymptomatic patients is highly variable.
Counting mast cells in gastrointestinal (GI) mucosal biopsies is becoming an increasingly common practice. The primary reason for (...)
Succinate dehydrogenase deficiency in pituitary adenoma; SDH-deficient pituitary adenoma
Germline mutations in the succinate dehydrogenase genes (SDHA, SDHB, SDHC, and SDHD) are established as causes of pheochromocytoma/paraganglioma, renal carcinoma, and gastrointestinal stromal tumor. It has recently been suggested that pituitary adenomas may also be a component of this syndrome.
Pathogenic SDH mutation may occur in pituitary adenomas and can be identified by immunohistochemistry, but (...)
prostate cancer with neuroendocrine differentiation
On July 31, 2013, the Prostate Cancer Foundation assembled a working committee on the molecular biology and pathologic classification of neuroendocrine (NE) differentiation in prostate cancer. New clinical and molecular data emerging from prostate cancers treated by contemporary androgen deprivation therapies, as well as primary lesions, have highlighted the need for refinement of diagnostic terminology to encompass the full spectrum of (...)