Genetically altered fields in head and neck cancer and second field tumor. Sabharwal R, Mahendra A, Moon NJ, Gupta P, Jain A, Gupta S. South Asian J Cancer. 2014 Jul;3(3):151-3. doi:10.4103/2278-330X.136766 . PMID: #25136520# [Free]
humpath.com supports the 2015 edition of the European Symposium of Biopathology, June 2015 in Paris, France.
Most recent articles
Head and neck squamous cell carcinoma of unknown primary is defined as the presence of squamous cell carcinoma in one or more lymph nodes within the head and neck region that are not solely in the supraclavicular region, without an identifiable primary tumor.
While many head and neck cancer patients initially present with a neck mass, the mucosally-based primary site of origin is typically identified via subsequent workup.
Squamous cell carcinoma of unknown primary is a relatively rare (...)
head and neck squamous cell carcinoma of unknown primary
squamous cell carcinoma of the parotid gland
Primary epidermoid carcinoma of major salivary glands is rare. The major risk factor is a history of radiotherapy of this gland.
It is important to rule out a metastasis of an epidermoid carcinoma from elsewhere on the head and the neck, or (rarely) metastasis from visceral cancer, such as lung cancer.
Squamous cell carcinoma involving the parotid gland is an aggressive and rapidly advancing lesion which if not recognized and treated early (...)
Cytologic Evaluation of the Enlarged Neck Node
I Bagwan, S Kane, R Chinoy. Cytologic Evaluation of the Enlarged Neck Node: FNAC Utility in Metastatic Neck Disease. The Internet Journal of Pathology. 2006 Volume 6 Number 2.. http://ispub.com/IJPA/6/2/11314
Building the graph of medicine from millions of clinical narratives, 2014 - http://dx.doi.org/10.5061/dryad.jp917
Jensen, P. B., Jensen, L. J. & Brunak, S. Mining electronic health records: towards better research applications and clinical care. Nat. Rev. Genet. 13, 395–405 (2012).
Cole, T. S. et al. Profiling risk factors for chronic uveitis in juvenile idiopathic arthritis: a new model for EHR-based research. Pediatr. Rheumatol. Online J. 11, 45 (2013).
Saria, S. et (...)
Strategies for annotation and curation of translational databases: the eTUMOUR project. Julià-Sapé M, Lurgi M, Mier M, Estanyol F, Rafael X, Candiota AP, Barceló A, García A, Martínez-Bisbal MC, Ferrer-Luna R, Moreno-Torres Á, Celda B, Arús C. Database (Oxford). 2012 Nov 22;2012:bas035. doi:10.1093/database/bas035 . Print 2012. PMID: #23180768# [Free]
ICD-10 represents the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (usually referred to as “ICD”), now overseen by the World Health Organization (WHO).
The overall goal of the ICD project is to standardize medical diagnosis and track diseases worldwide with the use of uniform codes to improve consistency among physicians and hospitals in recording patient symptoms and diagnoses. These systems are now also used to more accurately (...)
gastric ECL dysplasia
defined as large confluent micronodules of ECL cells lying deep in the mucosa, ranging from 150 to 500 microns in size.
microinfiltration of the lamina propria may be present.
newly formed stroma is occasionaly noted.
when the nodules are larger than 0.5 mm and confined to the mucosa, they are classified as microcarcinoids (or intramucosal carcinoid tumors).
Gastrin release from antral G cells is regulated by the following mechanisms:
luminal regulation: amino acids (particularly phenylalanine and tryptophan) are responsible for food-induced gastrin release. acidity of the gastric content is another major factor (alkaline pH is stimulatory and acidic pH is inhibitory).
H. pylori: by producing an alkaline pH by acid-neutralizing ammonia catalyzed by the bacterial urease. by production of stimulatory cytokines (interleukin-1 beta and (...)