Whipple’s Disease by Ed Euthman
Definition: Whipple’s disease (WD) is a chronic systemic inflammatory disease of infectious origin caused by Tropheryma whipplei (TW).
Abdominal pain and recurrent diarrhea are usually the main symptoms leading to the suspicion of a primary bowel disease. Systemic manifestations can mimic hematologic disorders.
Whipple disease (WD
Tropheryma whipplei-associated granulomatous (...)
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anal epidermoid carcinoma
80% of anal malignant tumors are squamous cell carcinomas (SCCs).
Anal cancer is an uncommon malignancy, accounting for only about 4% of all cancers of the lower alimentary tract.
The annual incidence is about 1 in 100,000. The incidence is higher in women and is increasing.
Anal canal tumours are usually poorly differentiated. They are more common in women and have a worse prognosis.
Systemic spread of anal cancer occurs in fewer than 10% of (...)
80% of anal cancers are squamous cell carcinomas (SCCs). Other tumour types include melanoma, lymphoma and adenocarcinoma. Tumour behaviour depends on its anatomical site of the primary cancer.
mucus producing cell
respiratory mucus producing cells
digestive mucus producing cells
Definition: Foveolar cells are mucus producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid.
Foveolar cells are also known as "surface mucous cells" or "mucous neck cells", depending on the location. These cells line the gastric mucosa and gastric pits.
The mucous secreting cells of the stomach can be distinguished histologically from the intestinal goblet cells.
Definition: Goblet cells are glandular simple columnar epithelial cells whose function is to secrete mucin, which dissolves in water to form mucus. They use both apocrine and merocrine methods for secretion.
The term goblet refers to these cells’ goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it is narrow for lack of these granules.
There are other cells that (...)
Definition: Intestinal metaplasia is the transformation (metaplasia) of epithelium, usually of the stomach or the esophagus , to a type that bears some resemblance to the intestine as seen in Barrett’s esophagus.
Chronic infection caused by H. pylori infection in the stomach and GERD in the esophagus are seen as the primary instigators of metaplasia and subsequent adenocarcinoma formation.
Initially, the transformed eptithelium bears resemblance to the small intestine; in the later (...)
Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases. Iourov IY, Vorsanova SG, Yurov YB. Curr Genomics. 2012 Sep;13(6):477-88. doi: 10.2174/138920212802510439 . PMID: #23449087# [Free]
Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains. Van der Aa N, Cheng J, Mateiu L, Esteki MZ, Kumar P, Dimitriadou E, Vanneste E, Moreau Y, Vermeesch JR, Voet T. Nucleic (...)
In the postgenome era, biology and medicine are rapidly evolving towards quantitative and systems studies of complex biological systems.
Emerging breakthroughs in microfluidic technologies and innovative applications are transforming systems biology by offering new capabilities to address the challenges in many areas, such as single-cell genomics, gene regulation networks, and pathology.
quantitative biomolecular analysis
systems biomolecular analysis (...)