Correlation of MUC4 expression with clinical outcomes may establish MUC4 as a potential molecular prognostic marker for these tumors. (#11226945#)
MUC4 (sialomucin complex) expression in salivary gland tumors and squamous cell carcinoma of the upper aerodigestive tract. Weed DT, Gomez-Fernandez C, Bonfante E, Lee TD, Pacheco J, Carvajal ME, Goodwin WJ, Carraway KL. Otolaryngol Head Neck Surg. 2001 Feb;124(2):127-41. PMID: (...)
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Most recent articles
primary parotid squamous cell carcinoma
secondary parotid squamous cell carcinoma
A primary of secondary lesions
In a series, 75% of patients have previous epidermoid skin lesions in an area known to drain to the parotid gland and 10% result from direct extension into the gland from an overlying skin carcinoma, whereas only 10% are primary lesions of the gland.
In this series (#3823246#), patients who presented with involvement of the gland more than 4 months after excision of (...)
fine needle aspiration of parotid masses
Selective fine needle aspiration of parotid masses. FNA should be performed in all patients older than 60 years. Kieran SM, McKusker M, Keogh I, Timon C. J Laryngol Otol. 2010 Sep;124(9):975-9. doi:10.1017/S0022215110001088 . PMID: #20497621#
A misdiagnosed keratoacanthoma turned out to be a metastatic parotid carcinoma. Tas E, Birol Ugur M, Gul A, Cinar F, Uzun L, Dogan Gun B. Acta Otorhinolaryngol Ital. 2010 Apr;30(2):115-7. PMID: #20559484#
Oral and oropharyngeal SCC can metastasize to the intraparotid lymph nodes. The inferior parotid nodes are most commonly involved, and patients generally have substantial associated cervical metastases.
When treating patients who have oral or oropharyngeal cancer with substantial cervical metastasis, physicians should consider removing the inferior parotid lymph nodes.
When intraparotid lymph node metastasis is detected, total parotidectomy and multidisciplinary adjuvant therapy should be (...)
Primary squamous cell carcinoma of the parotid gland: primary parotid SCC
Squamous cell carcinoma involving the parotid gland is an aggressive and rapidly advancing lesion which if not recognized and treated early will result in a high morbidity and mortality. Parotid gland squamous cell cancer (SCC) occurs as metastasis from cutaneous SCC or primary malignancy.
SCC is the second most common parotid malignancy, and its incidence is increasing (annual percentage change 1.7%; ptrend = (...)
Significance of clinical stage, extent of surgery and outcome in cutaneous squamous cell carcinoma of the head and neck. Košec A, Svetina L, Lukšić I. Int J Oral Maxillofac Surg. 2013 Jan;42(1):82-8. doi:10.1016/j.ijom.2012.10.007 . PMID: #23137734#
Cutaneous squamous cell carcinoma of the head and neck: management of the parotid and neck. Yilmaz M, Eskiizmir G, Friedman O. Facial Plast Surg Clin North Am. 2012 Nov;20(4):473-81. doi:10.1016/j.fsc.2012.07.007 . PMID: #23084299# (...)
Protein kinases are a large family of approximately 530 highly conserved enzymes that transfer a γ-phosphate group from ATP to a variety of amino acid residues, such as tyrosine, serine, and threonine, that serves as a ubiquitous mechanism for cellular signal transduction.
The clinical success of a number of kinase-directed drugs and the frequent observation of disease causing mutations in protein kinases suggest that a large number of kinases may represent therapeutically relevant targets. (...)
disease-causing mutation database
Genotype to phenotype via network analysis. Carter H, Hofree M, Ideker T. Curr Opin Genet Dev. 2013 Dec;23(6):611-21. doi:10.1016/j.gde.2013.10.003 . PMID: #24238873# [Free]
Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to clonal diversity.
Oral cavity and oropharyngeal squamous cell carcinoma genomics. Tan M, Myers JN, Agrawal N. Otolaryngol Clin North Am. 2013 Aug;46(4):545-66. doi:10.1016/j.otc.2013.04.001 . PMID: #23910469# [Free]
Tumor evolution and intratumor heterogeneity of an oropharyngeal squamous cell carcinoma revealed by whole-genome sequencing. Zhang (...)