Humpath.com - Human pathology

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• mucus producing cells

  1 May

  mucus producing cell
  Types
  goblet cells
  foveolar cells
  Location
  respiratory mucus producing cells
  digestive mucus producing cells

• digestive mucus producing cells

  1 May

  Types
  goblet cells
  foveolar cells

• foveolar cell

  1 May

  foveolar cells
  Definition: Foveolar cells are mucus producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid.
  Foveolar cells are also known as "surface mucous cells" or "mucous neck cells", depending on the location. These cells line the gastric mucosa and gastric pits.
  The mucous secreting cells of the stomach can be distinguished histologically from the intestinal goblet cells.
  See also
  goblet (...)

• goblet cell

  1 May

  goblet cells
  WP
  Definition: Goblet cells are glandular simple columnar epithelial cells whose function is to secrete mucin, which dissolves in water to form mucus. They use both apocrine and merocrine methods for secretion.
  The term goblet refers to these cells’ goblet-like shape. The apical portion is shaped like a cup, as it is distended by abundant mucinogen granules; its basal portion is shaped like a stem, as it is narrow for lack of these granules.
  There are other cells that (...)

• intestinal metaplasia

  1 May

  WP
  Definition: Intestinal metaplasia is the transformation (metaplasia) of epithelium, usually of the stomach or the esophagus , to a type that bears some resemblance to the intestine as seen in Barrett’s esophagus.
  Chronic infection caused by H. pylori infection in the stomach and GERD in the esophagus are seen as the primary instigators of metaplasia and subsequent adenocarcinoma formation.
  Initially, the transformed eptithelium bears resemblance to the small intestine; in the later (...)

• single-cell genomics

  1 May

  See also
  single-cell technology
  Open references
  Single cell genomics of the brain: focus on neuronal diversity and neuropsychiatric diseases. Iourov IY, Vorsanova SG, Yurov YB. Curr Genomics. 2012 Sep;13(6):477-88. doi: 10.2174/138920212802510439 . PMID: #23449087# [Free]
  Genome-wide copy number profiling of single cells in S-phase reveals DNA-replication domains. Van der Aa N, Cheng J, Mateiu L, Esteki MZ, Kumar P, Dimitriadou E, Vanneste E, Moreau Y, Vermeesch JR, Voet T. Nucleic (...)

• quantitative microfluidic biomolecular analysis

  1 May

  In the postgenome era, biology and medicine are rapidly evolving towards quantitative and systems studies of complex biological systems.
  Emerging breakthroughs in microfluidic technologies and innovative applications are transforming systems biology by offering new capabilities to address the challenges in many areas, such as single-cell genomics, gene regulation networks, and pathology.
  See also
  microfluidic technology
  quantitative biomolecular analysis
  systems biomolecular analysis (...)

• gastric endocrine cell

  30 April

  gastric endocrine cells
  Endocrine cells of the gastric oxyntic mucosa, and especially the enterochromaffin-like (ECL) cells, are the progenitors of gastrin-promoted proliferative lesions whose tumorigenic potential largely depends on the background condition in which they arise.
  Pathology
  gastric endocrine cell hyperplasia
  gastric carcinoid tumor

• multinucleate epithelial change in colorectal hyperplastic polyp

  30 April

  Multinucleate epithelial change in colorectal hyperplastic polyps
  Hyperplastic polyps containing multinucleated epithelial giant cells (MEGs) show active inflammation and apoptosis, and in most there was also focal inflammation and apoptosis in the adjacent mucosa.
  Inflammation in conjunction with the increased epithelial proliferation characteristics of hyperplastic polyps could be the mechanism for the MEG formation.
  References
  Multinucleate epithelial change in colorectal (...)

• CMV-associated inflammatory polyp

  30 April

  Cytomegalovirus infection as isolated inflammatory polyps of the gastrointestinal tract.
  Gastrointestinal involvement by cytomegalovirus (CMV) infection is a well recognised complication in patients taking steroid/immunosuppressive therapy or suffering from immunodeficiency and debilitating diseases. Rarely, CMV may affect immunocompetent healthy individuals. However, CMV infection presenting as isolated inflammatory polyps is unusual.
  References
  Cytomegalovirus infection presenting as (...)

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