Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to clonal diversity.
Head and neck squamous cell carcinoma (HNSCC) comprise a wide spectrum of neoplasms with different tumor biologies, prognosis and response to therapies.
Current tumor classification and traditional diagnostic methods (e.g. clinical assessment, histopathology) are limited in their capacity to determine prognosis and clinical decision-making. Despite (...)
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Most recent articles
Human papillomavirus-associated oral intraepithelial neoplasia
’HPV-associated Oral Intraepithelial Neoplasia’ is used to characterize the lesions of the oral cavity for consistency in nomenclature with HPV-associated lesions of the lower anogenital tract.
Human papillomavirus-associated oral intraepithelial neoplasia. Woo SB, Cashman EC, Lerman MA. Mod Pathol. 2013 Oct;26(10):1288-97. doi:10.1038/modpathol.2013.70 . PMID: #23599160# (...)
IgG4-related disease to lacrimal gland lesions
Applying the consensus statement on the pathology of IgG4-related disease to lacrimal gland lesions. Andrew N, Kearney D, Selva D. Mod Pathol. 2013 Aug;26(8):1150-1. doi:10.1038/modpathol.2013.46 . PMID: #23903493# [Free]
BRAFV600E in CRC; BRAFV600E in colorectal cancer
Excluding Lynch syndrome
In colorectal carcinoma, the presence of the BRAFV600E mutation can be used to virtually exclude Lynch syndrome in mismatch repair-deficient tumors.
Immunohistochemistry Facilitates Universal Screening of Colorectal Cancers for Lynch Syndrome. (#23797718#)
BRAFV600E mutation in microsatellite-unstable (MSI) colorectal carcinomas (CRCs) virtually excludes Lynch syndrome (LS).
Prognostic biomarker (...)
Mismatch repair protein immunohistochemistry is a widely used method for detecting patients at risk for Lynch syndrome.
Recent data suggest that a two-antibody panel approach using PMS2 and MSH6 is an effective screening protocol for colorectal carcinoma, but there are limited data concerning this approach for extraintestinal tumors.
Concurrent loss of MLH1 and PMS2 is the most common pattern of abnormal expression (12%) followed by concurrent loss of MSH2 and MSH6 (...)
TNM Staging System
T stages of salivary gland cancer
T1 means the tumour is all inside the tissue of the salivary gland and is smaller than 2cm across (about ¾ inch across)
T2 – the tumour is larger than 2cm, but smaller than 4cm across (about 1 ½ inches)
T3 – the tumour is bigger than 4cm and/or it has spread into the soft tissues around the salivary gland
T4a – the tumour has grown outside the salivary gland into nearby body tissues such as the jaw, ear canal, facial nerves or skin (...)
sebaceous epithelial-myoepithelial carcinoma of the parotid gland
Epithelial-myoepithelial carcinoma (EMCa) is a double-cell layered low-grade malignant tumor, representing approximately 1% of all salivary gland tumors.
Its histologic characteristic is that of an inner layer of cuboidal epithelial cells with dense granular cytoplasm and central or basal rounded nucleus, and an outer layer of clear, polygonal myoepithelial cells, together forming ductal structures in a lobulated papillary (...)
DICER1-associated renal sarcoma DICER1-associated renal rhabdomyosarcoma
DICER1-associated cystic nephroma
DICER1-associated sex cord tumors
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma. Doros LA, Rossi CT, Yang J, Field A, Williams GM, Messinger Y, Cajaiba MM, Perlman EJ, A Schultz K, Cathro HP, Legallo RD, LaFortune KA, Chikwava KR, Faria P, Geller JI, Dome JS, Mullen EA, Gratias EJ, Dehner LP, Hill DA.
Mod Pathol. 2014 Sep;27(9):1267-80. doi:10.1038/modpathol.2013.242 . PMID: #24481001# (...)
NB: A 8 kg historical tumor. (#10560870#)