Bosutinib (rINN/USAN; codenamed SKI-606, marketed under the trade name Bosulif) is a tyrosine kinase inhibitor (TKI) undergoing research for use in the treatment of cancer.
Originally synthesized by Wyeth, it is being developed by Pfizer.
Bosutinib: a SRC-ABL tyrosine kinase inhibitor for treatment of chronic myeloid leukemia. Rassi FE, Khoury HJ. Pharmgenomics Pers Med. 2013 Aug 5;6:57-62. PMID: (...)
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ganglion cyst of bone; Intraosseous ganglion
The intraosseous ganglion is a cystic lesion of bone most frequently located in the subchondral epiphysis of long bones without direct communication with a joint cavity.
Common radiologic features usually include a unilocular cyst surrounded by a thin rim of sclerotic bone in the subchondral epiphysis in the absence of other features of degenerative joint disease.
Histologically, the ganglia are usually composed of a cystic space without (...)
bone cystic lesions
infectious pulmonary diseases
occupational pulmonary diseases
tumoral pulmonary diseases (pulmonary tumors)
nodular silicosis simple silicosis complicated silicosis / progressive massive pulmonary fibrosis
rheumatoid pneumoconiosis (Caplan syndrome)
mixed dust fibrosis
diffuse interstitial fibrosis
Immune-mediated pulmonary diseases are a group of diseases that resulted from immune imbalance initiated by allergens or of unknown causes.
Inflammatory responses without restrictions cause tissue damage and remodeling, which leads to airway hyperactivity, destruction of alveolar architecture, and a resultant loss of lung function.
Epigenetic mechanisms have been demonstrated to be involved in inflammation, autoimmunity, and cancer.
Recent studies have identified that epigenetic changes (...)
Microscopic polyangiitis secondary to silica exposure
There is sufficient evidence of the capacity of silica to induce autoimmunity in patients with some type of genetic susceptibility.
There are several autoimmune diseases related to this exposure (rheumatoid arthritis, Sjögren’s syndrome, sarcoidosis, systemic sclerosis).
Nodular silicosis (clinical expression of this exposure in lungs) generates apoptosis, inflammation, loss of tolerance and a respiratory burst.
There is evidence that (...)
The silicosis is the pneumoconiosis more frequent, resulting from the inhalation of silica or silicates containing mineral dust, mainly characterized by irreversible lung fibrosis. It is associated with the development of other diseases, including pulmonary tuberculosis, lung cancer and autoimmune diseases.
The connective tissue disease after exposure to silica occurs usually after 15 years of initial exposure.The Erasmus syndrome describes the association of systemic sclerosis following (...)
Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product.
Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with (...)
The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.
This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma.
The type II cytokeratins are clustered in a region of (...)