WKP
Definition : Dupilumab, sold under the brand name "Dupixent", is a monoclonal antibody blocking interleukin-4 ( IL-4 ) and interleukin-13 ( Il-13 ), used for allergic diseases such as eczema (atopic dermatitis), asthma and nasal polyps which result in chronic sinusitis. It is also used for the treatment of eosinophilic esophagitis.
The aim of the humpath.com project is to constuct an ontology in human pathology, the study of anomalies and diseases in humans.
For more information, see : http://www.humpath.com/spip.php?article1
Most recent articles
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dupilumab
5 September -
Medlar bodies
23 AugustMedlar body
In chromoblastomycosis
Images
https://twitter.com/ASDPTweets/status/665166813626429440
https://twitter.com/PathoPictures/status/635793489528229888
https://twitter.com/VishwasParekh/status/710632555817598978
Medlar bodies https://twitter.com/goswami_malini/status/1561697081655726080 -
FH–deficient pheochromocytoma
23 AugustFumarate Hydratase–deficient Pheochromocytoma and Paraganglioma
Definition : Up to 40% of pheochromocytomas (PCCs) and paragangliomas (PGLs) are hereditary. Germline mutations/deletions in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma syndrome which manifests predominantly with FH-deficient uterine/cutaneous leiomyomas and renal cell carcinomas (RCCs)—tumors characterized by loss of immunohistochemical (IHC) expression of FH and/or positive staining for (...) -
mononuclear phagocyte system
23 Augustreticuloendothelial system WKP
Definition : In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the reticuloendothelial system or macrophage system is a part of the immune system that consists of the phagocytic cells located in reticular connective tissue.
The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of the MPS. (...) -
extracellular compartment
23 AugustPathology
pathology of collagen
pathology of elastin
pathology of basement membranes
pathology of proteoglycans
extracellular accumulations amyloidosis calcifications / calcium deposits -
cellular compartment
23 Augustcellular compartments
In developement
Developmental compartments can be simply defined as separate, different, adjacent cell populations, which upon juxtaposition, create a lineage boundary.
This lineage boundary prevents cell movement from cells from different lineages across this barrier, restricting them to their compartment.
Subdivisions are established by morphogen gradients and maintained by local cell-cell interactions, providing functional units with domains of different (...) -
exogenous
23 August -
endogenous
23 August -
substance
23 AugustChemical substance
Definition : A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., without breaking chemical bonds.
Chemical substances can be simple substances, chemical compounds, or alloys.
Types
endogenous substance
exogenous (...) -
organismal phenotype
23 AugustWKP
Definition: The organismal phenotype is the appearance of an organism with respect to a particular character or group of characters (physical, biochemical, and physiologic).
It is a result of the interaction of its genotype and its environment. This term is often used to define the consequences of a particular mutation.
See also
cellular phenotype
tissular phenotype
phenotype
phenotypic expression
standardized phenotyping protocols
phenotypic changes (...)
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