Humpath.com - Human pathology

Most recent articles

• prostatic cribriform anomalies

  13 July

  Cribriform Proliferations of the Prostate
  The presence of cribriform glands/ducts in the prostate can pose a diagnostic challenge.
  Cribriform glands/ducts include a spectrum of lesions, from benign to malignant, with vastly different clinical, prognostic, and treatment implications. Objective.—To highlight the diagnostic features of several entities with a common theme of cribriform architecture.
  Although relatively uncommon compared with small acinar lesions (microacinar carcinoma and (...)

• uterine mesenchymal tumors

  10 July

  Uterine mesenchymal tumors are genetically heterogenous; those with uniform cytomorphology, best exemplified by endometrial stromal tumors, often contain various fusion genes.
  Novel fusions involving ESR1 and GREB1 , key factors in sex hormone pathways, have been implicated in rare uterine mesenchymal tumors.
  Particularly, the fusions between 5’-ESR1/GREB1 and 3’-NCOA2/NCOA3 were recently identified in 4 uterine tumors resembling ovarian sex-cord tumor (...)

• GREB1-rearranged uterine sarcomas with variable sex-cord differentiation

  10 July

  Pathology
  GREB1-rearranged uterine sarcomas with variable sex-cord differentiation. Growth regulation by estrogen in breast cancer 1 / GREB1 is a protein that in humans is encoded by the GREB1 gene. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for (...)

• GREB1

  10 July

  WKP
  Definition : Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  Pathology
  GREB1-rearranged uterine sarcomas with variable (...)

• cytoplasm

  8 July

  See also : cytoplasmic anomalies , cytoplasmic appearance
  Examples
  cross striations
  cytoplasmic eosinophilia
  cytoplasmic basophilia
  cytoplasmic vacuolation
  clear cytoplasm / clear cell change
  cytoplasmic eosinophilia
  cytoplasmic inclusions
  cytoplasmic clarification
  See also
  morphological anomalies microscopical anomalies nuclear anomalies
  See also
  cellular anomalies nuclear (...)

• enlarged lymph node

  2 July

  enlarged lymph nodes
  Examples
  Progressive transformation of germinal centers (PTGC) https://twitter.com/MatthewMuscara/status/1093845323473215488

• enlarged lymphoid follicles

  2 July

  enlarged lymphoid nodules
  Examples
  Progressive transformation of germinal centers (PTGC) https://twitter.com/MatthewMuscara/status/1093845323473215488

• invagination of the mantle zone into the germinal center

  2 July

  Examples
  Progressive transformation of germinal centers (PTGC) https://twitter.com/MatthewMuscara/status/1093845323473215488

• reactive lymph node pattern

  2 July

  Examples
  Progressive transformation of germinal centers (PTGC) https://twitter.com/MatthewMuscara/status/1093845323473215488

• post-kala-azar dermal leishmaniasis

  27 June

  PKDL
  Post-kala-azar dermal leishmaniasis (PKDL) is a complication of visceral leishmaniasis (VL); it is characterised by a macular, maculopapular, and nodular rash in a patient who has recovered from VL and who is otherwise well.
  The rash usually starts around the mouth from where it spreads to other parts of the body depending on severity. It is mainly seen in Sudan and India where it follows treated VL in 50% and 5-10% of cases, respectively.
  Thus, it is largely restricted to areas (...)

previous page | next page