Humpath.com - Human pathology

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• infiltrative basal cell carcinoma

  22 May

  Infiltrating type
  This type, consisting of 10% of all BCC, includes non-sclerosing and sclerosing histological variants with an infiltrating rather than expansible growth pattern, where long, thin strands of tumour cells penetrate deeply among the collagen fascicles.
  The superficial layers of the tumour often have a solid growth pattern and the infiltrative type is present in the lower or peripheral layers of the tumour.
  If excision is not complete, this tumour can be included in the (...)

• nodular basal cell carcinoma

  22 May

  Nodular type (solid)
  Definition: The solid variant, also known as the large nest type, accounts for approxi­mately 70% of all cases. It is composed of islands of cells with peripheral palisading and a haphazard arrangement of the more central cells.
  This histological type represents, according to various authors, 30 to 75 % of all BCC. This wide range is influenced to a certain extent by the assignment or exclusion of similar growth types.
  The nodular histological type consists of cell (...)

• superficial basal cell carcinoma

  22 May

  Superficial type (multicentric, multifocal)
  This histological type, consisting of 10–15% of BCC is most frequently described in younger age categories. It consists of frequent small islets of basaloid tumour cells, well circumscribed against normal epithelia and in close contact but without apparent invasion; with papillary dermis.
  The nests are often surrounded by thin strands of fibrous stroma with lymphocyte infiltrate and thin-walled vessels. Multifocal development of this type is (...)

• ATG8

  22 May

  WP
  Diagnostic use
  autophagic vacuolar cardiomyopathy Autophagic vacuolar cardiomyopathy is an underrecognized, but potentially fatal, complication of treatment with chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), which are used as therapy for malaria and common connective tissue disorders. Currently, the diagnosis of autophagic vacuolar cardiomyopathy is established through an endomyocardial biopsy and requires electron microscopy, which is not widely available and has (...)

• drug-induced autophagic vacuolar cardiomyopathy

  22 May

  Autophagic vacuolar cardiomyopathy is an underrecognized, but potentially fatal, complication of treatment with chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), which are used as therapy for malaria and common connective tissue disorders.
  Currently, the diagnosis of autophagic vacuolar cardiomyopathy is established through an endomyocardial biopsy and requires electron microscopy, which is not widely available and has a significant potential for sampling error. (...)

• NUP62

  22 May

  info DKFZp547L134, FLJ20822, FLJ43869, IBSN, MGC841, "nuclear pore glycoprotein p62", p62, SNDI; info nucleoporin 62kDa WP
  Diagnostic use
  autophagic vacuolar cardiomyopathy Autophagic vacuolar cardiomyopathy is an underrecognized, but potentially fatal, complication of treatment with chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), which are used as therapy for malaria and common connective tissue disorders. Currently, the diagnosis of autophagic vacuolar (...)

• cytoplasmic positivity of TTF-1

  22 May

  cytoplasmic positivity of TTF1 eIHC
  Cytoplasmic staining with TTF-1 has been little studied. This cytoplasmic staining is due to a cross-reacting antigen of 160 kd, which is not an alternative splicing product of TTF-115.
  In a large series of consecutive cases, about 6% (23/361) of all tumours from a variety of sites showed cytoplasmic staining.
  hepatocellular carcinoma
  a minority of pulmonary adenocarcinomas show coarse granular cytoplasmic staining
  occasionally in squamous (...)

• CA-125

  22 May

  WP PO
  CA-125 (cancer antigen 125 or carbohydrate antigen 125) also known as "mucin 16" or "MUC16" is a protein that in humans is encoded by the MUC16 gene.
  MUC16 is a member of the mucin family glycoproteins.
  CA-125 has found application as a tumor marker or biomarker that may be elevated in the blood of some patients with specific types of cancers, or other benign conditions.

• mediastinal lymph nodes

  21 May

• Bowenoid papulosis

  20 May

  Bowenoid papulosis consists of one or more indolent, verrucous papules on the genitalia with a clinical resemblance to condyloma acuminatum and a histological resemblance to Bowen’s disease.
  HPV-16 is the most frequently detected HPV subtype detected in this condition. It usually responds to local therapies, but recurrences and the development of invasive carcinoma have been reported.
  The term ‘penile intraepithelial neoplasia’ (PIN) has been coined to encompass the three preinvasive (...)

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