Humpath.com - Human pathology

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• cholesterol granuloma

  9 January

  Cholesterol granuloma is also rare and is described as inflammatory granulation that occurs in response to the deposition of cholesterol crystals.
  Cholesterol granulomas are found most commonly in the paranasal sinuses or temporal bones, but there are also rare reports of their occurrence in the peritoneum, parotid gland, lymph nodes, thyroglossal duct, kidney, liver, and spleen.
  Localization
  bone (#23608269#) rib (#23608269#)
  Etiology
  Tangier disease
  References
  Cholesterol (...)

• crystals in lymph node

  9 January

  Types
  calcifications
  spherulitic calcification
  smooth calcification
  crystallized apatite
  whitlockite
  isolated and well-crystallized whitlockite
  cholesterol crystals
  sarcoisosis
  Rosai-Dorfman disease (#16121057#)
  Skin lesions can show classic features of cutaneous RDD with the additional feature of conspicuous rhomboidal and needle-shaped crystals within the cytoplasm of many lesional plasma cells, histiocytes, and also in an extra-cellular location. (#16121057#)
  drugs (...)

• eosinophilic crystal in breast duct

  9 January

  non-refractile eosinophilic crystal in breast ducts
  Reference
  Unusual nonrefractile eosinophilic crystal in breast ducts in a patient with invasive mucinous carcinoma. Quddus MR, Simon RA, Begum SM, Lomme M, Hansen K. Breast J. 2014 Jan-Feb;20(1):84-6. doi: 10.1111/tbj.12210. PMID: #24237484#

• BRCAs-associated breast cancer

  9 January

  BRCAs-associated mammary carcinoma
  Prognosis
  The prognosis of BRCA1/2-associated breast cancer partly depends on histologic characteristics. The majority of these breast cancers, however, is poorly differentiated. BRCA1-associated cancers are mainly negative for estrogen (ER), progesterone (PR) and HER2 receptor. Consequently, the use of these histologic features for risk stratification in BRCA1/2-breast cancer is limited.
  Tumor-associated inflammation density is the strongest predictor (...)

• lymph node calcification

  9 January

  Types
  spherulitic calcification
  smooth calcification
  crystallized apatite
  whitlockite isolated and well-crystallized whitlockite
  References
  Crystals and calcification patterns in two lymph node calcifications. Sakae T, Yamamoto H. J Oral Pathol. 1987 Oct;16(9):456-62. PMID: #3123624#

• therapeutic HPV vaccine

  6 January

  Open references
  Control of HPV-associated tumors by innovative therapeutic HPV DNA vaccine in the absence of CD4+ T cells. Peng S, Song L, Knoff J, Wang JW, Chang YN, Hannaman D, Wu TC, Alvarez RD, Roden RB, Hung CF. Cell Biosci. 2014 Mar 4;4(1):11. doi:10.1186/2045-3701-4-11 . PMID: #24594273# [Free]

• sarcomatoid mesothelioma vs fibrous pleuritis

  6 January

  Open References
  Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis. Wu D, Hiroshima K, Matsumoto S, Nabeshima K, Yusa T, Ozaki D, Fujino M, Yamakawa H, Nakatani Y, Tada Y, Shimada H, Tagawa M. Am J Clin Pathol. 2013 Jan;139(1):39-46. doi:10.1309/AJCPT94JVWIHBKRD . PMID: #23270897# (free)

• well-differentiated papillary mesothelioma

  6 January

  Subtype
  Well-differentiated papillary mesothelioma with invasive foci. (#24618613#)
  References
  Well-differentiated papillary mesothelioma with invasive foci. Churg A, Allen T, Borczuk AC, Cagle PT, Galateau-Sallé F, Hwang H, Murer B, Murty VV, Ordonez N, Tazelaar HD, Wick M. Am J Surg Pathol. 2014 Jul;38(7):990-8. doi:10.1097/PAS.0000000000000200 . PMID: #24618613#

• surface epithelial mesothelial proliferation

  6 January

  surface epithelial mesothelial proliferations
  References
  p16 FISH deletion in surface epithelial mesothelial proliferations is predictive of underlying invasive mesothelioma. Hwang H, Tse C, Rodriguez S, Gown A, Churg A. Am J Surg Pathol. 2014 May;38(5):681-8. doi:10.1097/PAS.0000000000000176 . PMID: #24503757#

• early colorectal cancer

  6 January

  Open references
  Endoscopic resection as unique treatment for early colorectal cancer. Revista Española de Enfermedades Digestivas. Rev. esp. enferm. dig. v.102 n.7 Madrid jul. 2010. http://dx.doi.org/10.4321/S1130-01082010000700006

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