Humpath.com - Human pathology

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• duodenal gastric heterotopia

  15 October

  Cases
  http://lgpathology.blogspot.fr/2008/07/50-yo-male-with-duodenal-polyp.html

• Morton neuroma

  15 October

  Morton’s neuroma; Morton’s metatarsalgia, Morton’s neuralgia, plantar neuroma and intermetatarsal neuroma WP
  Definition: Morton’s neuroma is a benign neuroma of an intermetatarsal plantar nerve, most commonly of the second and third intermetatarsal spaces (between 2nd-3rd and 3rd-4th metatarsal heads).This problem is characterised by pain and/or numbness, sometimes relieved by removing footwear.
  Despite the name, the condition was first correctly described by a chiropodist named (...)

• mycophenolate-associated colitis

  14 October

  Mycophenolate mofetil (MMF) is a T-cell inhibitor frequently used in the treatment of acute allograft rejection. MMF may cause colitis that clinically and histologically resembles graft-versus-host disease (GVHD).
  A variety of histologic features, in particular, eosinophils >15 per 10 HPF, lack of endocrine cell aggregates in the lamina propria, and lack of apoptotic microabscesses, can be used by pathologists to help separate MMF from GVHD-induced colitis in routine clinical practice. (...)

• pancreatic acinar cell cystadenoma

  14 October

  Acinar cell cystadenoma of the pancreas
  Acinar cell cystadenoma (ACA) of the pancreas was initially described as a non-neoplastic cyst of the pancreas and, at that time, referred to as "acinar cystic transformation." In subsequent studies, these lesions were given the designation of "-oma," despite the relative lack of evidence supporting a neoplastic process.
  Early lesions are marked by acinar dilatation that expands into and incorporates smaller ductules and later larger ducts. As the (...)

• vulvar squamous cell carcinoma.

  14 October

  Staging
  Stage 1a (#24076774#) Invasive squamous cell carcinoma of the vulva with ≤1 mm stromal invasion is classified as stage 1A. Cancer staging systems state that the depth of invasion should be measured from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of the invasive tumor. Measurement of the depth of invasion guides patient management. Even though this measurement is critical, no studies have reported the reliability among (...)

• intravascular adenomyomatosis

  14 October

  Intravenous leiomyomatosis (IVL) is a rare smooth-muscle proliferation that is of special interest because of its quasi-malignant behavior.
  Intravascular leiomyomatosis (IVL) is characterized by the presence of smooth muscle in venous and lymphatic spaces within the myometrium.
  Although the intravascular component usually consists solely of typical smooth muscle or variants of smooth muscle differentiation, some cases have been reported in which the intravascular component also included (...)

• radiation-induced basal cell carcinoma

  14 October

  radiation-induced cutaneous basal cell carcinoma
  Open References
  Multiple basal cell carcinomas arising in a surgical scar after radiotherapy. Husein-ElAhmed H. Ann Acad Med Singapore. 2012 Nov;41(11):536-7. PMID: #23235733# [Free]
  Radiation-related risk of basal cell carcinoma: a report from the Childhood Cancer Survivor Study. Watt TC, Inskip PD, Stratton K, Smith SA, Kry SF, Sigurdson AJ, Stovall M, Leisenring W, Robison LL, Mertens AC. J Natl Cancer Inst. 2012 Aug (...)

• SYK

  14 October

  spleen tyrosine kinase
  Open References
  The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M. Cancer Res. 2010 Aug 1;70(15):6193-204. doi:10.1158/0008-5472.CAN-08-3719 . PMID: 20670954 [Free]
  The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse (...)

• ITK

  14 October

  EMT, LYK, PSCTK2; IL2-inducible T-cell kinase
  Open References
  The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Dierks C, Adrian F, Fisch P, Ma H, Maurer H, Herchenbach D, Forster CU, Sprissler C, Liu G, Rottmann S, Guo GR, Katja Z, Veelken H, Warmuth M. Cancer Res. 2010 Aug 1;70(15):6193-204. doi:10.1158/0008-5472.CAN-08-3719 . PMID: 20670954 [Free]
  The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis (...)

• thecomatosis

  14 October

  Reference
  Luteinized Thecomas (Thecomatosis) Associated With Sclerosing Peritonitis Exhibit Positive Staining With Sex Cord Markers Steroidogenic Factor-1 (SF-1) and FOXL2.
  McCluggage WG, Staats PN, Gilks CB, Clement PB, Young RH. Am J Surg Pathol. 2013 Sep;37(9):1458-9. doi:10.1097/PAS.0b013e31829bafee . PMID: #24076780#

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